In the second edition of this groundbreaking text in non-Western philosophy, sixteen experts introduce some of the great philosophical traditions in the world. The essays unveil exciting, sophisticated philosophical traditions that are too often neglected in the western world. The contributors include the leading scholars in their fields, but they write for students coming to these concepts for the first time. Building on revisions and updates to the original, this new edition also considers three philosophical traditions for the first time—Jewish, (...) Buddhist, and South Pacific philosophy. (shrink)

Can the Internet reach beyond the U. S. college samples predominant in social science research? A sample of 564,502 participants completed a personality questionnaire online. We found that 19% were not from advanced economies; 20% were from non-Western societies; 35% of the Western-society sample were not from the United States; and 66% of the U. S. sample were not in the 18–22 (college) age group.

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

Background: Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy (...) also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection. Results: Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p < 0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia. (shrink)

Intracellular NLR (Nucleotide‐binding domain and Leucine‐rich Repeat‐containing) receptors are sensitive monitors that detect pathogen invasion of both plant and animal cells. NLRs confer recognition of diverse molecules associated with pathogen invasion. NLRs must exhibit strict intramolecular controls to avoid harmful ectopic activation in the absence of pathogens. Recent discoveries have elucidated the assembly and structure of oligomeric NLR signalling complexes in animals, and provided insights into how these complexes act as scaffolds for signal transduction. In plants, recent advances have provided (...) novel insights into signalling‐competent NLRs, and into the myriad strategies that diverse plant NLRs use to recognise pathogens. Here, we review recent insights into the NLR biology of both animals and plants. By assessing commonalities and differences between kingdoms, we are able to develop a more complete understanding of NLR function. (shrink)

Recent efforts in a range of scientific fields have emphasised research and methods concerning individual differences and individualisation. This article brings together various scientific disciplines—ecology, evolution, and animal behaviour; medicine and psychiatry; public health and sport/exercise science; sociology; psychology; economics and management science—and presents their research on individualisation. We then clarify the concept of individualisation as it appears in the disciplinary casework by distinguishing three kinds of individualisation studied in and across these disciplines: Individualisation ONE as creating/changing individual differences (the (...) process that generates differences between individuals: intrapopulation or intraspecific variation/heterogeneity); Individualisation TWO as individualising applications (the tailoring or customising of something—information, treatment, a product or service, etc.—for an individual or specific group of individuals); and Individualisation THREE as social changes influencing autonomy, risk, and responsibilities (the process discussed under the rubric of sociological individualisation theory). Moreover, we analyse conceptual links between individualisation and individuality, and characterise different sorts of individuality that the disciplines study. This paper aims to promote interdisciplinary research concerning individualisation by establishing a common conceptual-theoretical basis, while leaving room for disciplinary differences. (shrink)

Several themes can be identified in the commentaries. The first is that the climbing fibers may have more than one function; the second is that the climbing fibers provide sensory rather than motor signals. We accept the possibility that climbing fibers may have more than one function consequence(s)’ in the title. Until we know more about the function of the inhibitory input to the inferior olive from the cerebellar nuclei, which are motor structures, we have to keep open the possibility (...) that the climbing fiber signals can be a combination of sensory and motor signals. (shrink)

In our recent article, "Where Does Cumulative Culture Begin? A Plea for a Sociologically Informed Perspective" we commented on a fundamental notion in current approaches to cultural evolution, the “zones of latent solutions”, and proposed a modification of it, namely a social and dynamic interpretation of the latent solutions which were originally introduced within an individualistic framework and as static, genetically fixed entities. This modification seemed, and still seems, relevant to us and, in particular, more adequate for coping with the (...) archaeological record. Bandini et al. rejected our proposition and deemed it unnecessary. In their critique, they focused on: our reservations about an individualistic approach; our objections to the presumption of fully naive individuals; and our demand for an extended consideration of forms of social learning simpler than emulation and imitation. We will briefly reply to their critique in order to clarify some misunderstandings. However, the criticisms also show that we are at an impasse on certain crucial topics, such as the meaning of ZLS and the scope and nature of culture in general. Thus, we consider it necessary to make an additional effort to identify the conceptual roots which are at the very basis of the dissent with Bandini et al. (shrink)

In einer Zeit, in der Schelling Spätwerk erstmals die fachwissenschaftliche Diskussion bewegt und Strauß' kritischer Beitrag in Gefahr steht, vergessen zu werden, sucht die Arbeit das Gespräch mit den beiden Zeitgenossen. Sie fordert damit auf, die Frage nach der Reichweite der menschlichen Vernunft im christlichen Gottesdenken neu zu stellen und vertieft zu bedenken. Der Nicht-Mehr-Theologe Strauß negiert die inhaltliche Denkmöglichkeit der Offenbarung in seinem Frühwerk und spricht stattdessen vom menschengemachten "Mythos". Dem steht der positive Versuch des Noch-Nicht-Theologen Schelling gegenüber, der (...) in seine Spätphilosophie "Offenbarung" als Offenbarung des freien Gottes rekonstruiert. Imanente Ermächtigung und transzendente Entmächtigung des Subjekts bilden die Brennpunkte der Debatte. (shrink)

In einer Zeit, in der Schelling Spätwerk erstmals die fachwissenschaftliche Diskussion bewegt und Strauß' kritischer Beitrag in Gefahr steht, vergessen zu werden, sucht die Arbeit das Gespräch mit den beiden Zeitgenossen. Sie fordert damit auf, die Frage nach der Reichweite der menschlichen Vernunft im christlichen Gottesdenken neu zu stellen und vertieft zu bedenken. Der Nicht-Mehr-Theologe Strauß negiert die inhaltliche Denkmöglichkeit der Offenbarung in seinem Frühwerk und spricht stattdessen vom menschengemachten "Mythos". Dem steht der positive Versuch des Noch-Nicht-Theologen Schelling gegenüber, der (...) in seine Spätphilosophie "Offenbarung" als Offenbarung des freien Gottes rekonstruiert. Imanente Ermächtigung und transzendente Entmächtigung des Subjekts bilden die Brennpunkte der Debatte. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 111 A Critical History of Western Philosophy. Edited by D. J. O'Connor. (Giencoe: The Free Press, 1964. Pp. x + 604. $9.95.) Professor O'Connor and his collaborators have, in their Critical History of Western Philosophy, produced a novel and, to my mind, unusually good textbook. The volume, which is designed primarily as a text for undergraduate philosophy students, is made up of twentynine essays, each one devoted (...) to a major philosopher in the Western tradition--or, in a few instances, to a philosophical movement. The essays (29) have been written by 25 persons and each includes a sho[t biography of the philosopher under discussion followed by a fairly lengthy presentation and critical analysis of his philosophical views, with particular attention to metaphysics and epistemology. The contributors to the volume are mostly British, although they include a sprinkling of Americans and one Norwegian. This reviewer was pleased to note several representatives from the new British universities among them. The philosophers selected for study in the book have, I believe, been well chosen. The standard greats, from Plato through Hegel, are all included. In going beyond this repertory, the editor has used good judgment in his selections. It is always possible to question individual choices, but this proves only that different editors would produce different books. In the present ease, it might be argued that in making his selections from the seco~td rank the editor showed some partiality in favor of the insular over the continental tradition. There is, however, a quite reasonable reply to such an objection: that the selection of philosophers was determined by the purpose for which the book was designed--namely, to serve as a text for students in British and American universities. One of the problems in a book of this type, containing essays by more than two dozen writers, is to maintain a measure of uniformity--of style, of method, of complexity, and so on. Once again, the result seems to me to be on the whole successful. The essays in general are clearly written; they approach their subjects at a level that avoids oversimplification on the one hand, yet should almost always be intelligible to the average, studious undergraduate on the other. One notes an occasional idiosyneracy of interpretation; however, because the essays are written by different people, such peculiarities do not repeat themselves long enough to become an annoyance. Indeed, if I have any criticism to make on this point, it would be that the editor has been too successful in achieving uniformity in his essays. The result is writing that strikes me as being somewhat on the bland side, as though each of the contributors had made a conscious effort to produce an essay indistinguishable in anything but its content from all the others. I shall not attempt in this review to discuss critically the separate essays contained in the book. That would be an endless task, of dubious value. Instead I should like to raise two quite general issues that seem pertinent to the book as a whole. The first concerns the editor's statement, in the Preface, of the purposes of the book: In his words: "The writers have tried to do two things: (1) to explain the principal philosophical concepts and theories in the order in which they were developed; and (2) to evaluate and criticize them in the light of contemporary knowledge and to bring out whatever may be in them that is of permanent philosophical interest." The first of these two aims raises no questions; the second, however, is a different matter. I am puzzled, specifically, by its first clause, that the essays will evaluate and criticize past philosophical theories in the light of contemporary knowledge. Is this really a meaningful task? If the book were a history of science rather than of philosophy, I could understand how the writers might go about criticizing earlier theories in the light of contemporary knowledge. In philosophy, however, the situation is quite different. On what contemporary knowledge can one base his criticisms? Most of us recognize the prodigious advances that have been made during our century in the accumulation of empirical knowledge. If by contemporary... (shrink)

Little is in print on the development in Britain of university disciplines including the academic study of education. This paper provides a historical narrative of the study of adolescence from the 1870 Education Act to the contemporary day. Adolescence textbooks are examined in the context of changes in the education system, such as the demand for secondary education and the expansion of teacher education. Changing emphases in adolescence research are traced through various publications to illustrate curriculum developments. The important contributions (...) of Dame Olive Wheeler, Professor W. D. Wall and other leading writers on adolescence are evaluated. It is clear that in over a century of national educational provision British teachers have never faced a great choice of adolescence texts and the paper concludes with some reflections on this observation. (shrink)

P. KOnig: Einleitung - P. ZIche: Idiographik und allgemeine Wissenschaftlichkeit - Windelband und die Wissenschaftsreflexion um 1900 - G. HArtung: Ein Philosoph korrigiert sich selbst - Wilhelm Windelbands Abkehr vom Relativismus - O. SChlaudt: Philosophie am Leitfaden der Empirie. WIndelbands relativistisches Programm - S. KUft: Windelbands Konzeption von Transzendentalphilosophie und ihr Bezug zur Kulturphilosophie - R. BOnito Oliva: Windelband. KUlturphilosophie und Kulturkrise - P. KOnig: Teleologie und Geschichte bei Wilhelm Windelband - J. BOhr: Im Fortschreiben der Probleme: Windelbands 19. JAhrhundert (...) - T.-H. CHang: Der Wertbegriff beiWilhelm Windelband und sein Konzept der Problemgeschichte - T. KUbalica: Die Geschichte der Philosophie als Problemgeschichte - J. MEhlich: Windelbands Praludien und das Silberne Zeitalter in Russland - G. SChluter: Windelbands italienische Kontakte und Bezugnahmen - D. STefanelli: Notizen uber Karl Vossler und die "Sudwestdeutsche Schule" - C. ZAnfi: Geschichte, Natur und Leben: Windelband und Bergson in der Historismus-Debatte - J.-I. LIndén: Der beseelte Geist: Dilthey als Kritiker der badischen Schule - H. GUndlach: Windelbands Ringen mit der Psychologie - Anhang: Wilhelm Windelband: Blaue Hefte zur Psychologie. (shrink)

The concept of divine justice has been the subject of considerable scrutiny in recent philosophical theology, as it bears upon the notion of punishment with respect to the doctrine of eternal damnation. In this essay, I set out a version of the traditional retributive view of divine punishment and defend it against one of the most important and influential contemporary detractors from this position, Thomas Talbott. I will show that, contrary to Talbott’s argument, punishment may satisfy divine justice, and that (...) perfect justice is commensurate with retribution, rather than, as he suggests, reconciliation and restoration. (shrink)

We agree that the relationship between phenomenology and accessibility can be fruitfully investigated via meshing, but we want to emphasise the importance of proper comparison between meshes, as well as considerations that make comparison especially difficult in this domain. We also argue that Block's interpretation of the neural data in his exemplar mesh is incorrect, and propose an alternative.

I present an annotated development of the basic ideas of the Geneva School approach to the foundations of physics and the structures which emerge as mathematical representations of the physically dual notions of state and property.